Endocrine Abstracts

Introduction: Mixed connective tissue disease (MCTD), also known as Sharp´s syndrome is a rare autoimmune disease (AD), characterized by the presence of high titers of a distinctive autoantibody: ribonucleoprotein auto-antibody (anti-RNP). It presents with varied overlapping symptoms of different connective tissue disorders which may appear sequentially over time. As other AD, MCTD may be associated with one or more AD, such as autoimmune thyroid disorders (AITD).<p c...

Introduction: Type 1 diabetes mellitus (T1DM) is the result of the autoimmune destruction of beta-cells of the endocrine pancreas, leading to absolute insulin deficiency. The process of this autoimmune destruction occurs in genetically susceptible individuals with positive relevant autoantibodies. T1DM may be associated with other autoimmune diseases (AD) such as autoimmune thyroid disorders (AITD). Patients and methods: It is a descriptive retrospective...

Introduction: Autoimmune hepatitis (AIH) is a generally progressive and chronic liver disease that can occur both in children and adults. Although the cause of AIH is unknown, aberrant auto-reactivity is thought to have a role in its pathogenesis. The diagnosis is based on clinical presentation, biological and histological findings. Like other autoimmune diseases (AD), AIH can be associated with one or more AD either organ-specific or non-organ specific AD. <p class="abste...

Introduction: Hashimoto’s encephalopathy (HE) is characterised by the combination of clinical signs of encephalitis and autoimmune thyroiditis with elevated levels of antithyroid antibodies (ATA). It is a rare condition and its etiopathogenesis is still poorly understood.Observation: we present a 33-year-old female patient who was hospitalized for gait disorders. The diagnosis of a chronic cerebellar syndrome related to Hashimoto’s encephalitis...

Introduction: Hypothyroidism is a consequence of thyroid hormone deficiency which may be of peripheral or central origin. If hypothyroidism is left untreated, the symptoms progress and lead to life-threatening complications.Patients and method: Retrospective study of 67 patients with primary hypothyroidism. We determined the different complications associated with hypothyroidism.Results: We collected 67 patients with overt hypothyr...

Introduction: Autoimmune bullous dermatoses (ABD) represent a heterogeneous group of AIDs that target different epidermal or subepidermal proteins of the skin and/or mucous membranes. As with any autoimmune disease (AID), it may be associated with other AIDs. We report a case of ABD associated with Graves’ disease (GD).Observation: The ABD was a pemphigus vulgaris (PV) that was diagnosed at the age of 25 years in our patient and she was treated with...

Introduction: Alopecia is an autoimmune disease (AID) affecting the hair follicles. Alopecia can become generalised and affect all hairy areas (universal alopecia). As with any AID, it may be associated with other AIDs. We report 2 cases of the association of alopecia with autoimmune thyroid disease (AITD).Observation: The subjects were a man and a woman aged 48 and 54 years respectively. They presented with hypothyroidism. Hashimoto’s thyroiditis (...